Pharmacokinetic Interactions of Bisoprolol and Rosuvastatin

Inclusion Criteria: * Male volunteers in the age between 20 and 55 years old(inclusive) * Body mass index (BMI) in the range of 18.5 to 27 kg/m2(inclusive) * Medically healthy with no clinically significant vital signs (sitting position blood pressure, pulse rate) (90 mmHg ≤ systolic blood pressure ≤ 150 mmHg, 60 mmHg ≤ diastolic blood pressure ≤ 100 mmHg, 50 beats per minute ≤ pulse rate ≤ 100 beats per minute) * Available for the entire study period * Understand the requirements of the study and voluntarily consent to participate in the study Exclusion Criteria: * Subjects with a history of gastrointestinal diseases which might significantly change ADME(Absorption, Distribution, Metabolism and Excretion) of medicines * History of clinically significant arrhythmic, peripheral vascular,thyroid, bronchospasm, asthma disease * Subjects with anaphylaxis to bisoprolol and/or rosuvastatin * History of drug abuse * History of caffeine, alcohol, smoking abuse * caffeine(coffee,tea,coke) or grapefruit juice \> 4cups/day * smoking \> 20 cigarettes/day * alcohol \> 140g/week * Clinical laboratory test values are outside the accepted normal range * AST(Aspartate Transaminase), ALT(ALanine Transaminase)( \> 1.5 times to normal range * CK(Creatine Kinase) \> 1.5 times to normal range * Estimated GFR(Glomerular Filtration Rate) \< 60 mL/min * Subjects with whole blood donation within 60days, component blood donation within 30days and blood transfusion within 30days prior to study medication dosing * Subjects considered as unsuitable based on medical judgement by investigators