Microbiota Restoration Therapy for Recurrent Clostridium Difficile-associated Diarrhea

Inclusion Criteria: * ≥ 18 years * Medical record documentation of CDAD either: a) at least two recurrences after a primary episode and have completed at least two rounds of standard-of-care oral antibiotic therapy or b) have had at least two episodes of severe CDAD resulting in hospitalization. * Willing and able to have an enema(s). * Already taking or will start a course of oral antibiotics for CDAD symptoms for 10-14 days, including at least seven days of oral vancomycin. * Willing and able to complete the required subject diary. Exclusion Criteria: * Continued (uncontrolled) CDAD after completing a 10-14 day course of oral antibiotics. * Requires antibiotic therapy for a condition other than CDAD. * Previous fecal transplant prior to study enrollment. * History of inflammatory bowel disease (IBD), e.g., ulcerative colitis, Crohn's disease, or microscopic colitis. * History of irritable bowel syndrome (IBS). * History of chronic diarrhea. * History of celiac disease. * History of cirrhosis of the liver or ascites. * Disease symptoms caused by a confirmed intestinal pathogen other than Clostridium difficile. * Has a colostomy. * Intraabdominal surgery within the last 60 days. * Evidence of active, severe colitis. * History of short gut syndrome or motility disorders. * Requires the regular use of medications that affect bowel motility (e.g., metoclopramide, narcotics, loperamide). * Planned therapy in the next 3 months that may cause diarrhea (e.g., chemotherapy). * Planned surgery requiring perioperative antibiotics within 6 months of study enrollment. * Life expectancy of \< 12 months. * Compromised immune system, e.g., HIV infection (any CD4 count); AIDS-defining diagnosis or CD4 \<200/mm3; inherited/primary immune disorders; immunodeficient or immunosuppressed due to a medical condition or medication; current or recent (\< 90 days) treatment with chemotherapy; or current or recent (\< 90 days) treatment with immunosuppressant medications. * Taking steroids (≥ 20 mg a day) or is expected to be on steroids for more than 30 days after enrollment. * Neutropenia (white blood cell count \<1000 cells/µL).