The purpose of this study is to investigate the effect of micellar curcumin on inflammation and lipid metabolism markers in subjects at risk for the metabolic syndrome.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
42
80 mg micellar curcumin (oral) three times a day for six weeks
Only the excipients (without curcumin) used to prepare the curcumin micelles are given as placebo.
Institute of Biological Chemistry and Nutrition, University of Hohenheim
Stuttgart, Baden-Wurttemberg, Germany
C-reactive protein (CRP)
Serum CRP in mg/L
Time frame: At baseline and 6 weeks
Plasma curcumin concentrations
Concentrations (in nmol/L) of curcumin and curcumin conjugates in plasma
Time frame: At baseline and 6 weeks
Serum alanine transaminase activity
Serum activity of ALT in U/L
Time frame: At baseline and 6 weeks
Fasting blood glucose
Fasting blood glucose in mmol/L
Time frame: At baseline and 6 weeks
Plasma tumor necrosis factor alpha
Plasma concentrations of TNFα in pg/mL
Time frame: At baseline and 6 weeks
Serum uric acid
Serum concentrations of uric acid in g/L
Time frame: At baseline and 6 weeks
Plasma albumin
Plasma concentrations of albumin in g/L
Time frame: At baseline and 6 weeks
Serum total cholesterol
Serum total cholesterol in mmol/L
Time frame: At baseline and 6 weeks
Serum triacylglycerols
Serum triacylglycerols in mmol/L
Time frame: At baseline and 6 weeks
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Serum HDL cholesterol
Serum HDL cholesterol in mmol/L
Time frame: At baseline and 6 weeks
Serum LDL cholesterol
Serum LDL cholesterol in mmol/L
Time frame: At baseline and 6 weeks
Serum aspartate transaminase activity
Serum activity of AST in U/L
Time frame: At baseline and 6 weeks
Serum gamma glutamyl transferase activity
Serum activity of gamma-GT in U/L
Time frame: At baseline and 6 weeks
Serum alkaline phosphatase activity
Serum activity of ALP in U/L
Time frame: At baseline and 6 weeks
Serum bilirubin
Serum concentrations of bilirubin in g/L
Time frame: At baseline and 6 weeks
Plasma interleukine 6
Plasma concentrations of IL-6 in pg/mL
Time frame: At baseline and 6 weeks
Serum insulin
Serum concentrations of insulin in pg/mL
Time frame: At baseline and 6 weeks
Body weight
Body weight in kg
Time frame: At baseline and 6 weeks
Diastolic blood pressure
Diastolic blood pressure in mmHg
Time frame: At baseline and 6 weeks
Serum creatinine
Serum concentrations of creatinine in g/L
Time frame: At baseline and 6 weeks
Systolic blood pressure
Systolic blood pressure in mmHg
Time frame: At baseline and 6 weeks