Optimal Regimen in Endovascular Therapy in Ischemic Cerebrovascular Disease Based on Clopidogrel Resistance

Inclusion Criteria: * symptomatic ischemic cerebrovascular disease caused by Intracranial atherosclerotic atherosclerosis research database. * 90 days had a stroke or transient ischemic attack is defined as symptomatic Intracranial atherosclerotic atherosclerosis * stenosis ≥ 50% (MRI or CT angiography). * Intracranial vascular stenosis measured according to the method reported Warfarin aspirin symptomatic intracranial disease research. Exclusion Criteria: * diffuse intracranial arterial stenosis. * cranial magnetic resonance imaging shows lesions as the branch artery blockage caused. * non-atherosclerotic lesions. * occurred within 6 weeks of vascular lesions in the region of intracranial hemorrhage. * potential cardiac thrombus source. * has concurrent intracranial tumors, intracranial aneurysm or arteriovenous malformation. * ipsilateral extracranial carotid or vertebral artery stenosis ≥ 50%; * known to heparin, aspirin, clopidogrel, anesthetics and contrast agents contraindications; * hemoglobin less than 10g/dL, platelet count \<100000/dL; * responsibility left after cerebral vascular-related serious neurological dysfunction (mRS ≥ 3); * international normalized ratio\> 1.5 * there are factors that can not be corrected by bleeding; * life expectancy \<1 year; * pregnant or lactating women; * indications Commission determines that the patient is not suitable for the study treatment.