Nasal Intermittent Positive-Pressure Ventilation for Twin Infants With Respiratory Distress Syndrome

N/ACompletedNCT01926106

Daping Hospital and the Research Institute of Surgery of the Third Military Medical University286 enrolled

Overview

In the present study, we hypothesized that primary mode nIPPV initiated shortly after birth would decrease the incidence of intubation or death in twin infants when compared to nCPAP.

After inclusion of eligible twins infants,one of the twins was supported by nCPAP and another nIPPV.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SUPPORTIVE_CARE

Masking

QUADRUPLE

Enrollment

286

Conditions

Neonatal Respiratory Distress Syndrome

Interventions

nIPPVDEVICE

one of the twins was randomly allocated to nIPPV

nCPAPDEVICE

another of the twins was allocated to nCPAP

Eligibility

Sex: ALLMin age: 30 MinutesMax age: 6 Hours

Medical Language ↔ Plain English

Inclusion Criteria: * Twins * Clinical diagnosis of mild-moderate respiratory distress syndrome * requiring a fraction of inspired oxigen (FiO2 ) \<0.40 to keep oxygen saturation of 90%-95% * a chest X-ray suggestive of early stage hyaline membrane disease, (i.e. mild microgranulia and air bronchogram) Exclusion Criteria: * pneumothorax * pneumomediastinum * surgical diseases * cardiac diseases * intraventricular hemorrage * major congenital defects

Locations (1)

Department of Pediatrics, Daping Hospital, Research Institute of Surgery, Third Military Medical University

Chongqing, Chongqing Municipality, China

Outcomes

Primary Outcomes

incidence of intubation

Time frame: 48h

Secondary Outcomes

incidence of BPD

Time frame: 1 month

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.