TMS for CRPS - Pilot Study

N/ACompletedNCT01926119

Stanford University4 enrolled

Overview

The purpose of this pilot study is to test whether Transcranial Magnetic Stimulation (TMS) may alleviate the symptoms of Complex Regional Pain Syndrome (CRPS). The investigators will test various methods of TMS in a small pilot study to investigate what methods may have clinical potential. This is a small pilot study to determine feasibility and signal to potentially inform future trials.

Study Type

INTERVENTIONAL

Allocation

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Complex Regional Pain Syndrome (CRPS)

Interventions

Transcranial Magnetic StimulationDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. Age 18 or older 2. Diagnosis of CRPS (complex regional pain syndrome) 3. Average pain level reported on Numerical Rating Scale meets entry criteria 4. Ability to perform the experimental task and procedures. Exclusion Criteria: 1. MRI contraindication (metal implants or devices, claustrophobia) 2. TMS Contraindication (eg metal implant or devices near the site of stimulation) 3. History of epilepsy 4. History of a psychological or psychiatric disorder that would interfere with study procedures, at the discretion of the researcher. 5. Neurologic illness that would interfere with brain integrity 6. Current medical condition or medication use that would interfere with study procedures or data integrity, at the discretion of the researcher. 7. Currently pregnant or planning to become pregnant. 8. On going legal action or disability claim.

Locations (1)

Stanford University School of Medicine

Palo Alto, California, United States

Outcomes

Primary Outcomes

Change in Pain

Numerical rating scale (NRS) where 0=no pain and 10=worst pain imaginable

Time frame: Baseline to post-TMS day 5

Secondary Outcomes

Change in Motor Function and Coordination

As assessed by functional capacity exam and physical exam

Time frame: End of 5-day treatment series and at 1-week follow-up relative to baseline

Change in Sensory Perception

Time frame: End of each treatment session and at 1-week follow-up as compared to baseline

Change in Vasomotor Function

Time frame: End of each treatment session and at 1-week follow-up as compared to baseline

Change in Sudomotor Function

Time frame: End of each treatment session and at 1-week follow-up as compared to baseline

Trophic Changes

Time frame: End of each treatment session and at 1-week follow-up as compared to baseline

Change in Motor Strength and Joint Range of Motion

Time frame: End of each of the 5 treatment sessions and at 1-week follow-up relative to baseline

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.