Cerebrovascular Autoregulation in Sepsis, Influence of Renal Replacement Therapy

N/AWithdrawnNCT01926301

Johannes Gutenberg University Mainz

Overview

The cerebrovascular autoregulation is impaired in patients with severe sepsis and septic shock. A continuous veno-venous hemodialysis may improve impaired cerebrovascular autoregulation. Hypothesis: continuous hemodialysis recovers impaired cerebrovascular autoregulation in patients with acute severe sepsis and septic shock.

Study Type

OBSERVATIONAL

Conditions

Severe Sepsis Septic Shock

Interventions

continuous veno-venous hemodialysisPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * severe sepsis or septic shock * adult patients * possibility of transcranial Doppler ultrasound Exclusion Criteria: * traumatic brain injury * known cerebrovascular diseases * Infection of the brain * chronic renal failure * pregnancy

Locations (1)

University Medical Center of the Johannes Gutenberg-Univerity

Mainz, Germany

Outcomes

Primary Outcomes

Cerebrovascular autoregulation

Cerebrovascular autoregulation measured daily at the first 4 days of severe sepsis and septic shock

Time frame: during the first 4 days

Secondary Outcomes

Delirium

Incidence of Delirium at day 4 after severe sepsis or septic shock

Time frame: at day 4

Data from ClinicalTrials.gov

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