The purpose of this study is to evaluate the potential secondary beneficial effect of prostaglandin analogues (PA) treatment in thyroid eye disease (TED) patients. This study aims to determine if PA would change the course of the orbitopathy in TED patients by altering the progression of the common features of TED, including fatty hypertrophy, proptosis, eyelid retraction and optic nerve compression. The eyes with thyroid eye disease and elevated intraocular pressure will be randomised to the PA treatment and the other eye will serve as a control eye and will be treated with Timolol.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
SINGLE
The first choice drug from group of Prostaglandin Analogues will be bimatoprost, if patient will suffer from any side effect of this drug another drug from this group will be administer. If patient turned out to cannot tolerate the prostaglandin analog therapy then the exclusion criteria will be met.
Timolol topical eye drop will be administered in Prostaglandin Analog vs Timolol arm only, in patients with elevated intraocular pressure in both eyes.
Stanford Hospital and Clinics
Stanford, California, United States
Change from baseline in appearance of facial periorbital region at 6 months.
Time frame: Baseline and 6 months
Change from baseline in Hertel exophthalmometry at 3, 6, 9 and 12 months.
Time frame: Baseline and 3, 6, 9 and 12 months
Change from baseline in intraocular pressure at 3, 6, 9 and 12 months.
Time frame: Baseline and 3, 6, 9 and 12 months
Change from baseline in appearance of facial periorbital region at 3, 6, 9 and 12 months.
Time frame: Baseline and 3, 6, 9 and 12 months
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