Recombinant Human Hyaluronidase in Treating Lymphedema in Patients With Cancer

Inclusion Criteria: * Eastern Cooperative Oncology Group (ECOG) performance status 0 or 2 * Unilateral upper limb secondary lymphedema * Must have the ability to understand and the willingness to sign a written informed consent document * Must agree to blood serum assessment including, complete blood count (CBC) with differential; comprehensive metabolic panel and serum osmolality at every sanctioned evaluation; additionally physician may require cardiac evaluation with echocardiogram, electrocardiogram, brain natriuretic peptide or urinalysis if deemed appropriate * Must consent to multi-bio-frequency impedance analysis (MFBIA); the details are to be covered in consent * Willing to sign consent for skin biopsies and phlebotomy * Women of child bearing potential must have a documented negative pregnancy test within 2 weeks prior to day 1 of treatment and agree to use a non-hormonal form of birth control during the duration of the trial therapy Exclusion Criteria: * Pregnant or actively breast-feeding * Bilateral upper extremity edema * Bilateral manipulation of axilla within the last 24 months * Active infections * Receiving concomitant treatment for upper extremity lymphedema, or who have received treatment within the last 14 days * Known allergic or hypersensitivity reaction to rHUPH20 or any hyaluronidase extracts * Receiving concomitant diuretics or dihydropyridine class of calcium channel blockers; if an alternative medication is available, patient can become eligible after 3 half-lives of drug discontinued and patient remains medically stable * Grade 2 or greater hypo-albuminemia, serum sodium greater than 150meq/L, serum osmolality greater than 300mOsm/kg or blood urea nitrate/serum creatinine ratio greater than 25, within 7 days of screening * Unable or unwilling to self/home administer subcutaneous experimental drug; study nurse or physician will train individuals on proper administration techniques * Unwilling or incapable of maintaining a detailed log of number of injections, the date, time and site of administration * Active malignancy; those undergoing active treatment for malignancy in the adjuvant setting are eligible; treatment can include chemotherapy, targeted therapy or anti-hormonal therapy * At least 4 weeks removed from surgery or radiation in affected arm * Primary lymphedema; if edema can be explained by systemic or congenital illnesses, that patient will not be eligible for this study * Must not have any concurrent condition which in the investigator's opinion makes it inappropriate for the patient to participate in the trial or which would jeopardize compliance with the protocol * Must not have received any investigational agents within 30 days prior to commencing study treatment * Active thrombophlebitis * Pulmonary edema, congestive heart failure or pulmonary embolus