Comparison of Adequacy of Anesthesia Monitoring With Standard Clinical Practice During Routine General Anesthesia

Inclusion Criteria: * Ability to provide written informed consent * Age 18-80 years of age * Surgery that is expected to last at least 2 hours under general anesthesia with endotracheal tube Exclusion Criteria: * Any subject that meets the definition of vulnerable subject as defined in ISO 14155:2011 * Per ISO 14155:2011, a vulnerable subject is defined as an individual whose willingness to volunteer in a clinical investigation could be unduly influenced by the expectation, whether justified or not, of benefits associated with participation or of retaliatory response from senior members of a hierarchy in case of refusal to participate * Any subject with a cardiac pacemaker * Any subject with atrial fibrillation at the time of obtaining the baseline values * Any subject with more than 5 ventricular extra systoles/minute at the time of obtaining the baseline values * Any subject who needs invasive blood pressure measurement * Any subject who show hemodynamics that would have qualified for being considered as a sign of inadequate anesthesia already at baseline: * Mean blood pressure below 60 mmHg or above 100 mmHg * HR below 45 /min or above 100/min * Any subject with epidural anesthesia or analgesia during the surgery. Epidural catheter may be placed pre-operatively, and used in the PACU, but not during the surgery * Any subject having surgery that requires prone position * Any subject with very high body mass index (\>35) because of incompatibility with the target controlled anesthesia models used * Any subject with known allergies to the specific anesthetic agents/ analgesic drugs intended for use in their surgeries * Any subject with laryngeal mask airway * Any subject who requires neuromuscular blocking agent infusion * Any subject who is going to have major surgery with a high risk of extensive blood loss * Any subject with known chronic use of opioids