Effects of Heating Transfusion on Brain Function

N/ACompletedNCT01930305

General Hospital of Ningxia Medical University100 enrolled

Overview

To inversitage whether routine warming of blood is harmful to brain fuction of sugical patients receiving massive transfusion.

Hypothermia is an effective therapeutic intervention to reduce hypoxic ischemia brain injury in animal experiments and in clinics.In a recent study, it has been shown that perioperative warming was associated with a higher incidence of cognitive dysfunction in elderly patients.Therefore, we hypothesised that perioperative heating transfusion have a side effect on brain function of surgical patients.

Study Type

OBSERVATIONAL

Enrollment

100

Conditions

Blood Transfusion

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * adult patients scheduled for major surgery under general anesthesia and they probably need a blood transfusion during the procedure. Exclusion Criteria:•Patients with a history of stroke, central nervous system disease , metabolic disturbance, psychiatric illness, hearing impairment, drug abuse or unwilling to participate in assessment \-

Locations (2)

General Hospital of Ningxia Medical University

Yinchuan, Ningxia, China

Ningxia Medical University

Yinchuan, Ningxia, China

Outcomes

Primary Outcomes

Brain fuction during perioperative period

Brain function includes cerebral blood flow and cerebral oxygen saturation

Time frame: Change from baseline at post-transfusion 15min, 30min, 1hour, 2hour, 3 hour, 6hour, 12hour, 24hour

Secondary Outcomes

the cognitive performance and the score of postoperative quality recovery scales ( PQRS)

Time frame: Chang from baseline at 15min,40min,1day,3day and 7day postoperative lay

Data from ClinicalTrials.gov

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