Gastric bypass (GBP) and laparoscopic adjustable banding (AGB) are common procedures that can result in significant weight loss and significantly improve type 2 diabetes in 40-80% of cases. The mechanism and time course of these changes have not been well studied and are poorly understood. The primary aim of this study is to investigate the potential weight-independent mechanisms of diabetes remission after GBP, by comparing GBP and AGB subjects after similar weight loss.
All participants will be tested before and then after 10 and 20-30% weight loss after either GBP or AGB surgery. Subjects will undergo an oral glucose tolerance test (OGTT) an isoglycemic intravenous glucose test (IVGT) to assess the incretin effect, a measure of insulin sensitivity by an intravenous insulin sensitivity test (IVGTT) and body composition measurements.
Study Type
OBSERVATIONAL
St. Luke's Roosevelt Hospital-New York Obesity Nutrition Research Center
New York, New York, United States
Change in Incretin Effect
Effect of GBP and AGB on incretin hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory peptide (GIP)
Time frame: Before surgery, 1, 12, and 24 months post
Change in Body Composition
Body composition measurements to determine body volume, size, and fat
Time frame: Before surgery, 12, and 24 months post
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.