In an 8 week double blind randomized controlled split-face studies, we tried to compare the clinical efficacy, safety and histopathological changes between Lactobacillus fermented Chamaecypris obtusa (LFCO) and existing tea tree oil (TTO) Basically, this is a split face study - one side of face randomly assigned was applied with LFCO and the other side with TTO in same patients.
Screening of natural compounds for the development of anti-acne therapeutic agents has been steadily required considering various side effects of acne medications.However, previous studies have mainly focused on experimental tests without clinical trials and histopathological analysis. To compare the clinical efficacy, safety and histopathological changes between Lactobacillus fermented Chamaecypris obtusa (LFCO) and existing tea tree oil (TTO) Total thirty four patients were instructed to apply 5 % LFCO to the involved areas of randomly allocated side and 5 % TTO extract to the other side for 8 weeks in a double blind split-face clinical trial.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
34
Application of LFCO (Lactobacillus fermented Chamaecypris obtusa ) containing creams to one randomly selected face of patients to monitor its effectiveness and safety of acne treatments.
Application of TTO (Tea tree oil) containing creams to the other side of face of patients to monitor its effectiveness and safe compared with LFCO.
Department of Dermatology, Seoul National University College of Medicine
Seoul, South Korea
Number of inflammatory and non-inflammatory acne lesions
Compared to baseline, number inflammatory and non-inflammatory acne lesions were counted to check out the effectiveness \& safety of two botanical compounds
Time frame: total 8 weeks after baseline
Patient's subjective assessments for comfortableness & efficacy
Patients are required to report subjective assessments for comfortableness \& efficacy for two creams they used
Time frame: 8 weeks after baseline
Sebum secretion assessment
Patients' sebum secretion from face was measured by sebumeter to detect sebum secretion changes after applying two components.
Time frame: 8 weeks after baseline
Histopathologic analysis
changes of tissue after application of two creams
Time frame: 8 weeks after baseline
Adverse effects
patients' reportings for severe side effects after application of two creams was monitored.
Time frame: 8 weeks after baseline
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