18F-NaF PET Imaging for Bone Scintigraphy

All Subject Inclusion Criteria * All subjects must have a WHO performance status 0-2. * Subjects ≥ 18/19 years of age (depending on the age of majority in the province where the trial is conducted) For Prostate Cancer: Male subjects requiring a bone scan for evaluation of bone metastasis with one (or more) of the following criteria: * Symptomatic subjects with clinically suspected bone metastases based on a history of non-joint skeletal pain or non-joint skeletal tenderness on physical examination. The physician must have a high index of suspicion based on history or physical examination, such as night time pain or new onset of pain unexplained by trauma. Such subjects must have a measurable PSA level ≥ 4 ng/mL. * Subjects with findings on other examinations (such as plain x-ray, CT, MRI or bone scintigraphy and others) that are suspicious for bone metastases but not conclusively diagnostic of bone metastases. * Asymptomatic subjects with newly diagnosed localized prostate cancer\[1\] and biopsy Gleason sum 8 -10 (e.g. scores 3+5, 5+3, 4+4, 4+5, 5+4 or 5+5) prior to treatment. * Asymptomatic subjects with newly diagnosed localized prostate cancer\[1\] and biopsy Gleason score (4+3) and either PSA level ≥ 20 or palpable disease (cT2b or greater) prior to treatment. * Asymptomatic subjects with newly diagnosed localized prostate cancer\[1\] with PSA level ≥ 20 and palpable disease (any cT2 or greater) prior to treatment. * Asymptomatic subjects with a prior history of treated prostate cancer, and rising PSA, with a PSA doubling time \< 6 months, and a minimum PSA level ≥ 4 ng/mL * Asymptomatic subjects with a prior history of treated prostate cancer, and rising PSA while under androgen deprivation therapy, with a clearly measurable PSA doubling time \< 6 months (treatment does not need to be discontinued for eligibility). Notes: \[1\] Subjects with newly diagnosed prostate cancer who receive androgen deprivation therapy, for a duration of \< 6 months at the time of enrolment, prior to radiation therapy or surgery, remain eligible to participate in this study if they meet these inclusion criteria. For Breast Cancer: Subjects (male or female) requiring a bone scan for evaluation of bone metastasis with one (or more) of the following criteria (19-23): * Symptomatic subjects with clinically suspected bone metastases based on a history of non-joint skeletal pain or non-joint skeletal tenderness on physical examination. The physician must have a high index of suspicion based on history or physical examination, such as night time pain or new onset of pain unexplained by trauma. * Subjects with findings on other examinations (such as plain x-ray, CT, MRI or bone scintigraphy and others) that are suspicious for bone metastases but not conclusively diagnostic of bone metastases. * Asymptomatic subjects with newly diagnosed extra-skeletal metastatic breast cancer (stage IV). * Asymptomatic subjects with elevated serum cancer antigen (CA) 15.3 or alkaline phosphatase and newly diagnosed locally advanced breast cancer (Stage III). * Asymptomatic subjects with nodal or extra-skeletal metastatic relapse during follow-up after curative-intent therapy. * Asymptomatic subjects with new elevation of CA 15.3 or alkaline phosphatase during follow-up after curative-intent therapy. Subject Exclusion Criteria * Pregnancy. * Inability to lie supine for the duration of the imaging studies. * Subjects previously known for bone metastasis diagnosed by imaging or biopsy.