PaneLux PTCA : Proposing an Alternative Treatment to patiEnts for Whom DES Implantation is Not Indicated, Thanks to Pantera LUX Drug Eluting Balloon

Inclusion Criteria: 1. Subject has provided a written informed consent 2. Subject \>/= 18 years. 3. Patient affiliated to social security 4. Patient acceptable candidate who accept to be contacted at different terms of clinical follow up (1, 6 and 12 months) 5. Subject eligible for percutaneous coronary intervention AND undergoing a chronical oral anticoagulant treatment OR undergoing any semi-urgent invasive or non cardiac surgical planned intervention with major bleeding risks 6. Subject eligible for Dual Anti Platelet Therapy (DAPT) of acetyl salicylic acid and clopidogrel for at least 3 weeks 7. De Novo coronary lesions: \>/= 50% - \<100% 8. Subject, vessels and target lesion eligible for angioplasty with PRO-Kinetic Energy stent implantation and final post-dilatation with Pantera Lux drug eluting balloon. 9. Target lesion length \</= 26 mm , visual estimation or by Quantitative Coronary Angiography (QCA) 10. Reference diameters targeted vessels \>/=2.5mm and \</= 4.0 mm (visual estimation or QCA) Exclusion Criteria: 1. Pregnant or breast feeding females or females who intend to become pregnant during the time of the study 2. Subject with a life expectancy less than 1 year 3. Vulnerable subject, protected by law, unable to give his/her consent 4. Subject currently enrolled in other medical or drug study and has not reached the primary outcome measures of that study 5. Subject unable to be contacted for the clinical follow up at 1, 6 and 12 months 6. Subject under chronical oral anti-coagulant treatment (optionnal indication) 7. Subject undergoing any urgent invasive or surgical intervention with major bleeding risk, which can not maintain dual anti-platelet therapy (DAPT) for at least 3 weeks 8. In stent restenotic lesion 9. Target lesion on vessels with nominal diameter \< 2.5 mm 10. Target lesion is located in or supplied by an arterial or venous bypass graft 11. Chronical Total occlusion (CTO) 12. Angioplasty indication for STEMI 13. Patient with signs of cardiogenic shock 14. Angioplasty antecedent with stent implantation (before 12 months for DES, before 6 months for BMS) 15. "Staged procedure" \> 8 days after the initial angioplasty 16. Documented left ventricular ejection fraction (LVEF) \</= 30% 17. Target lesion requiring before stent implantation a device other than a pre-dilatation balloon (including, but not only restricted to laser, cutting balloon, directional coronary atherectomy, rotational atherectomy etc…) 18. Known allergies to acetylsalicylic acid, active agent such Paclitaxel, Expicients like BHTC (Butiriltri-n-hexyl citrate), CoCr, Silicon Carbide.