Genetic Profile on Predicting Sensibility of Preoperative Chemoradiotherapy on Locally Advanced Rectal Carcinoma

Inclusion Criteria: * Pathologically confirmed rectal adenocarcinoma, preoperative stage II / III (T3-4N0 or T1-4N + M0). * Distance from the lower bound of tumor to the anal verge is less than 12 cm. * KPS score not less than 70 * Can be tolerated chemotherapy and radiotherapy. * No history of radiation therapy to the pelvis. * Non-allergic history of fluorouracil or platinum-based chemotherapy drugs. * Full understanding of the study, the ability to complete all of the treatment plan, follow up the conditions and sign the informed consent. - Exclusion Criteria: * Other malignancy (past or at the same time), does not include curable non-melanoma skin cancer and cervical carcinoma in situ; does not include resectable primary colon cancer (synchronous or metachronous). * Pregnant or lactating patients. * Fertility but did not use contraceptive measures. * Existing active infection. * Merge serious complications, can not tolerate the treatment, such as 6 months of myocardial infarction, mental illness, uncontrollable diabetes or uncontrollable hypertension or hypotension. * Concurrent treatment with other anticancer drugs. * Can not complete treatment or follow-up