Study Evaluating Absorption, Distribution, Metabolism and Excretion (ADME) of Single Dose [14C] Selumetinib in Volunteers

Inclusion Criteria: * Provision of signed and dated, written informed consent prior to any study specific procedures. * Have a body mass index (BMI) between 18 and 32 kg/m2 inclusive and weigh at least 50 kg and no more than 100 kg, inclusive. * Regular bowel movements (ie, on average production of at least 1 stool per day). Exclusion Criteria: * Current or past history of central serous retinopathy or retinal vein thrombosis, intraocular pressure greater than 21 mmHg or uncontrolled glaucoma. * Exposure to radiation levels above background exceeding 5 mSv in the last 12 months or 10 mSv in the last 5 years. * History or presence of any clinically significant disease or disorder in the opinion of the investigator * Any clinically important abnormalities in clinical chemistry, haematology, or urinalysis results, vital signs or ECG at baseline in the opinion of the Investigator.