A Pilot Study for Pharmacokinetic Parameter of Colchicine in Patient Taking Rifampin

Inclusion Criteria: * from 18yrs to 80yrs , man and women * the patient who are taking rifampicine over 2weeks * the patient sign on the concent form Exclusion Criteria: * the patient have experience to take medication that have an effect on renal function * the patient have hypersensitivity to colchicine * At least, the average level of two separate blood pressure ( 2min interval ) shows that SBP \<= 100 mmHg or \>=160 mmHg and DBP \<=60 mmHg \>=100 mmHg, or Heart rate \< 40 beats/min or \> 90 beats/min * uncontrolled hypertension * serum albumin \< 3.5, \> 5 g/dL * acute hepatitis or the level of AST or ALT is over 2times of normal range or the level of bilirubin is over 2.0 mg/dL * the patient who have gastro-intestinal disease ( ex, crohn's disease, acute or chronic pancreatitis, ulcer )or who have the surgical history of gastrointestine. * the patient who should take azathioprine, mercaptopurine, cyclophosphamide, Losartan, benzbromarone,fenofibrate,furosemide ,probenecid * the patient who had taken part in the other study within 3months * the patient who had gotten blood transfusion * pregnant, breast feeding