A Study on the Inter-Hemispheric Alpha Ratio in Kids With ADHD (SHARK)

N/ACompletedNCT01932398

Radboud University Medical Center60 enrolled

Overview

Investigate the hypothesis that children with ADHD have difficulty with the allocation of visio-spatial attention related to an inability to control posterior alpha brain oscillations. A paradigm will be used in which the aim is to address covert attention as similar recent studies did in adults with ADHD.

Study Type

OBSERVATIONAL

Enrollment

Conditions

ADHD

Eligibility

Sex: ALLMin age: 84 MonthsMax age: 95 MonthsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: For both groups * Age between 7 and 10 years of age. * Estimated IQ above 80. * Psychopharmaca- naïve or -free. For the ADHD-group - A diagnosis of ADHD, classified by the DSM-IV. Exclusion Criteria: * (Co-morbid) psychiatric disorder (major depression, bipolar disorder, psychotic disorder, chronically motor tic disorder or Gilles de la Tourette, Conduct disorder, autism spectrum disorder, eating disorder, anxiety disorder). * Neurological disorders (e.g. epilepsy) currently or in the past. * Cardiovascular disease currently or in the past. * Serious motor or perceptual handicap. For the no ADHD-group \- No diagnosis of ADHD, classified by the DSM-IV.

Locations (1)

Donders Institute for Brain, Cognition and Behavior, Centre for Cognitive Neuroimaging

Nijmegen, Gelderland, Netherlands

Outcomes

Primary Outcomes

Modualtion of alpha power

Modulation\* of alpha power on congruent and incongruent trials of the covert attention task in 30 ADHD children and in 30 non-ADHD children \*Modulation is the (expected) cue-induced change by a covert attention task.

Time frame: Once for half an hour

Secondary Outcomes

Response time on covert attention task

Time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children

Time frame: Once for half an hour

Standard deviation of response time on covert attention task

The variation of the time it takes to press the correct button after presentation of target-stimulus on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children

Time frame: Once for half an hour

Correct responses on covert attention task

Number of correct button presses responses (i.e. same side as the target) on the covert attention task on congruent and incongruent trials of the covert attention task in 30 ADHD children and 30 non-ADHD children

Time frame: Once for half an hour

Mean deviation from middle on line bisection task

Mean deviation in mm from the center of the line on the line bisection task for 30 ADHD children and 30 non-ADHD children

Time frame: Once in about 5 minutes

Inattention score on the ADHD-RS-IV

The inattention subscale of the ADHD-RS-IV for 30 ADHD children and 30 non-ADHD children

Time frame: Once in about 10 minutes

Data from ClinicalTrials.gov

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