To evaluate the metabolism and routes and extent of elimination of telotristat etiprate and its primary metabolite LX1033.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
8
500 mg dose of LX1606 containing a target dose of 3.32 Megabecquerel (MBq) of radiation as \[14C\]-LX1606.
Lexicon Investigational Site
Nottingham, United Kingdom
Maximum plasma concentration of LX1606 and LX1033
Time frame: 7 days
Time to maximum plasma concentration of and LX1033
Time frame: 7 days
Determination of total radioactivity in blood and plasma
Time frame: 7 days
Mass balance recovery of total radioactivity in urine and feces
Time frame: 7 days
Metabolite profiling and identification in plasma
Time frame: 7 days
Metabolic profiling and identification in urine
Time frame: 7 days
Metabolic profiling and identification in feces
Time frame: 7 days
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