Effect of Intrathecal Administration of Hematopoietic Stem Cells in Patients With Amyotrophic Lateral Sclerosis (ALS)

Inclusion Criteria: * patients with a confirmed diagnosis of ALS according to El Escorial criteria. Diagnosis-time less than four years. * Over 18 years old. Forced vital capacity ≥ 40%. * One year of evolution. * Adequate nutritional state Exclusion Criteria: * Severe bulbar ALS involucre. * Inadequate nutritional status. * Spondylotic myelopathy, or abnormalities in imaging study. * Having concomitant neurological or psychiatric disease. * Systemic disease with poor-control. * History of treatment with steroids or immunoglobulins in the last year. * Participate in the past three months in a Clinical Trial. * History of malignancy or cancer today. * Intracranial hypertension. * Clinical suggestive data of infection in the site of lumbar puncture. * Tracheostomy. * Use of mechanical ventilation. Forced vital capacity less than 40%. HIV-seropositive or presence of antibodies against hepatitis B or C in the serological studies.