The purpose of this study is to determine whether intraoperative restrictive fluid management guided by pulse pressure variation produces a better effect on the postoperative lung function, kidney function, inflammatory response and short-term outcome after esophagectomy and reconstruction.
Measurements: intraoperative Lung injury score, Lung water index, Pulmonary vascular Permeability Index Measurements: intraoperative and postoperative Plasma creatine, C reactive protein (CRP), lactate, Neutrophil gelatinase-associated lipocalin (NGAL), Interleukin-6 (IL-6), Interleukin-8 (IL-8)
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
SINGLE
Enrollment
7
Intraoperative fluid therapy is directed by pulse pressure variation to a setting value, above 18% or below 13%.
Department of Anesthesiology, National Taiwan University Hospital
Taipei, Taiwan
postoperative lung function, kidney function, inflammatory response
plasma creatinine, CRP, lactate, NGAL, IL-6, IL-8
Time frame: from introperative to postoperative day 2
postoperative short-term outcome
Respiratory complication, cardiovascular complication, acute renal failure, another complications
Time frame: the duration of hospital stay, about 4 weeks
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