This study will test the potential for PF-05089771 to interact with a cocktail of drugs
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
17
PF-05089771 450mg single dose and titration from 150mg BID to 450mg BID Pravastatin 10mg dingle dose, Midazolam 7.5mg single dose, Losartan 25mg single dose, Caffeine 100mg single dose, Omeprazole 20mg single dose
Pfizer Investigational Site
Brussels, Belgium
Maximum Observed Plasma Concentration (Cmax)
Time frame: 24h
Area Under the Curve From Time Zero to Last Quantifiable Concentration (AUClast)
Area under the plasma concentration time-curve from zero to the last measured concentration (AUClast)
Time frame: 24h
Minimum Observed Plasma Trough Concentration (Cmin)
Time frame: 24h
Time to Reach Maximum Observed Plasma Concentration (Tmax)
Time frame: 24h
Change from Baseline in Lipid Parameters
Mean Total Cholesterol (TC), Low Density Lipoprotein (LDL), High Density Lipoprotein (HDL), and Triglyceride blood concentrations.
Time frame: 14 days
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