Urea Cream Treatment Sorafenib-Associated HSFR in HCC

Inclusion Criteria: * The patients with hepatocellular carcinoma will receive sorafenib per instructions of the package insert * The patients with hepatocellular carcinoma must be willing to participate in this study and provide the investigators with written consents; * The patients must be willing and able to complete the biweekly visits for the first 3 months; * The patients must be willing and able to fill in the patient's efficacy questionnaires. If the patients cannot use pens or pencils, the patient's acquaintances or the clinical staffs will complete these questionnaires based on the answers provided by the patients * The patients must discontinue all prior cancer treatment in at least 3 weeks before enrollment; * The patient's life expectancy is ≥3 months * The patients must provide written informed consents Exclusion Criteria: * The patients participated in other clinical trials * The patients received sorafenib therapy prior to enrollment * The patients combined other treatment or used other biological therapy, chemotherapy, experimental treatment or radiotherapy * The patient's sorafenib dosage exceeds 400mg, twice daily