A Phase I Study of AK159 in Healthy Postmenopausal Women

Inclusion Criteria: * Healthy postmenopausal ethnic Japanese women * At least 45 years of age at the time consent is obtained * Give voluntary consent in writing with a sufficient understanding of the study. Exclusion Criteria: * Clinical abnormality identified in the laboratory tests * Weight \< 40.0 kg * Body mass index \< 17.5 or \>=30.5 * History of disease of the kidneys, liver, heart, brain, or other organ that makes them ineligible as subjects * Previously received radiation treatment potentially affecting bone * Clinical abnormality identified in the 12-lead ECGs performed at the study center during the screening period * Systolic blood pressure \< 90 mmHg * Serum calcium level exceeding 10.4 mg/dL * History of contact dermatitis or skin disease potentially compromising study evaluation * Used drugs which impact bone metabolism in the 8-week period preceding investigational product administration * Used a bisphosphonate * Used a teriparatide product