Investigating Brown Adipose Tissue Activation in Humans

N/ACompletedNCT01935791

Imperial College London11 enrolled

Overview

The purpose of this study is to determine what can activate brown adipose tissue (BAT).

We will investigate different stimuli (i.e. hormones) to determine which can stimulate BAT.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Metabolic Diseases

Interventions

Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT VehicleOTHER

Temperature

Period 1 Visit 1 - Cold PET-CT Vehicle, Visit 2 -Warm PET-CT GlucagonDRUG

Hormone

Period 1 Visit 1 - Cold PET-CT Vehicle, no visit 2 as BAT negativeOTHER

Temperature

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * aged \>18 years Exclusion Criteria: * medical conditions * recreational drug use * participation in other trials within the preceding 2 months * blood donation within 3 months of study participation

Locations (1)

Imperial College London

London, United Kingdom

Outcomes

Primary Outcomes

Brown Adipose Tissue Activation Following Glucagon or Saline Infusion

Period 1 Brown Adipose Tissue (BAT) activation measured using metabolic rate of glucose (MR\[gluc\]) during F-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET-CT) for Cold PET-CT Vehicle vs Warm PET-CT Vehicle vs warm PET-CT Glucagon.

Time frame: 2hours

Increase in Energy Expenditure Following Glucagon or Saline Infusion

Period 2 Increase in energy expenditure measured using indirect calorimetry for Cold control vs Warm Control vs Warm Glucagon.

Time frame: 2hours

Data from ClinicalTrials.gov

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