This clinical trial will study the effects of PUFA supplementation during pregnancy and lactation period on fatty acid composition in human milk and plasma of the mothers and the clinical outcome of atopic dermatitis in infants at increased risk.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Masking
QUADRUPLE
International Peace Maternity and Child Health Hospital of China welfare Institute
Shanghai, Shanghai Municipality, China
Lipid Analysis
Time frame: Baseline, Delivery, Within one week after delivery, 6 weeks postpartum, 4 months postpartum
Metabolomics Study of PUFA
Time frame: Baseline, Delivery, Within one week after delivery, 6 weeks postpartum, 4 months postpartum, 12 months postpartum
Skin Prick Test to Common Allergens
Time frame: 4 months postpartum, 12 months postpartum
Clinical Assessment of IgE-mediated Allergic Eczema
Time frame: 4 months postpartum, 12 months postpartum
Fatty Acid Desaturase (FADS) Genotypes
Time frame: Baseline
immunoglobulin E immunoglobulin E Immunoglobulin E (IgE) Antibodies
Time frame: Baseline
Immunological Biomarkers
Time frame: 4 months postpartum, 12 months postpartum
Medically-confirmed adverse events collected throughout the study period
Time frame: 12 months postpartum
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