Alpha-1 Anti-Trypsin (AAT) Treatment in Acute Myocardial Infarction

Inclusion Criteria: * Acute STEMI defined as chest pain (or equivalent) with an onset within 12 hours and ECG evidence of ST segment elevation (\>1 mm) in 2 or more anatomically contiguous leads that is new or presumably new * Planned or completed coronary angiogram for potential intervention * Age\>21 Exclusion Criteria: * Inability to give informed consent * Hemodynamic instability as defined as need for inotropic or vasoactive agents, or need for mechanical support devices (including intra-aortic balloon pump) * Pregnancy * Preexisting congestive heart failure (American Heart Association/American College of Cardiology class C-D, New York Heart Association III-IV) * Preexisting severe left ventricular dysfunction (EF\<20%) * Preexisting severe valvular heart disease * Known active infections (acute or chronic) * Recent (\<14 days) or active use of anti-inflammatory drugs (not including NSAIDs or corticosteroids used for IV dye allergy only) * Known chronic inflammatory disease (including but not limited to rheumatoid arthritis, systemic lupus erythematosus) * Known active malignancy of any type, or prior diagnosis in the past 10 years * Anticipated need for cardiac or major surgery * Known active cancer (or prior diagnosis of cancer within the past 10 years) * Known Immunoglobulin A (IgA) deficiency