Comparable Study of Different Radiation Dose in Esophageal Carcinoma

Inclusion Criteria: * Histological or cytologic diagnosis of esophageal carcinoma * ECOG performance status 0-1 * Age:18-70 years * Joined the study voluntarily and signed informed consent form * Patients must not have received any prior anticancer therapy * Unresectable disease, or refuse surgery.Stage Ⅰ-ⅣA（AJCC 2009） * Target lesions can be measured according to RECIST criteria * No serious system dysfunction and immuno-deficiency, Adequate organ function including the following: Hemoglobin ≥9 g/dL, WBC≥3x109/L, Neutrophils (ANC )≥1.5x109/L, platelet count ≥100x 109/L, TBIL\<1.5 x ULN, ALT and AST ≦ 2.5 x ULN, creatinine ≦ 1.5 x ULN * Use of an effective contraceptive for adults to prevent pregnancy * Life expectancy of more than 3 months Exclusion Criteria: * Multiple carcinomas of the esophagus, * Biopsy-proven invasion of the tracheobronchial tree or tracheoesophageal fistula, * Metastatic disease (M1), * A primary tumor that extended to within 2 cm of the gastroesophageal junction, * Prior chemotherapy, prior thoracic radiation, surgical resection of the primary tumor, * Concurrent pregnancy or lactation, history of a second malignancy other than nonmelanoma skin cancer