The purpose of this study is to determine the feasibility and efficacy of preoperative nimotuzumab injection combined with concurrent chemoradiotherapy for initially inoperable, locally advanced cervical cancer.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
40
Nimotuzumab 200mg per week will be administered concurrent with platinum-based chemotherapy and intensity-modulated radiation therapy. After the preoperative treatment, patients will be assessed for tumor response and operability. For those who are considered to be candidates for operation, radical surgery will be performed. \--------------------------------------------------------------------------------
People's Hospital of Guangxi Zhuang Autonomous Region
Nanning, Guangxi, China
RECRUITINGTreatment related toxicities
Acute and chronic toxicities.
Time frame: at 1 year
Tumor response after preoperative treatment
Time frame: assessed at 4-5 weeks after the completion of preoperative treatment
Progression-free survival
Time frame: at 1 year
Overall survival
Time frame: at 1 year
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