NCT01938300 - Magnesium and Rotational Thromboelastometry (ROTEM) in Colorectal Cancer Surgery | Crick | Crick

Magnesium and Rotational Thromboelastometry (ROTEM) in Colorectal Cancer Surgery

N/ACompletedNCT01938300

Seoul National University Bundang Hospital44 enrolled

Overview

Magnesium sulphate is given to the patients during the colorectal cancer surgery under the hypothesis that it would attenuate the postoperative hypercoagulability. The investigators intend to characterize the changes of coagulation in colorectal cancer patients by using the point-of-care device after the infusion of magnesium sulphate.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

44

Conditions

Colorectal Cancer

Interventions

Magnesium SulfateDRUG

Normal salineDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The patients undergoing a laparoscopic colorectal cancer surgery Exclusion Criteria: * Renal disease * Hepatic disease * Neuromuscular disease * Coagulation disorder * Cardiopulmonary disease

Locations (1)

Seoul National University Bundang Hospital

Seongnam-si, Gyeonggi-do, South Korea

Outcomes

Primary Outcomes

Change of maximum clot firmness (MCF) of FIBTEM

Time frame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day

Change of Clotting time (CT) of INTEM

Time frame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day

Change of Clot firmness time (CFT) of INTEM

Time frame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day

Change of Alpha angle of INTEM

Time frame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day

Change of MCF of INTEM

Time frame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day

Change of CT of EXTEM

Time frame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day

Change of CFT of EXTEM

Time frame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day

Change of Alpha angle of EXTEM

Time frame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day

Change of MCF of EXTEM

Time frame: 1 day before a operation, 1 hour after finishing a operation, and a postopearative 3 day

Secondary Outcomes

Change of Hemoglobin

Data from ClinicalTrials.gov

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