Development of Clinical Assessment Technique Using Multi-radiotracer PET/MR in Prostate Cancer

N/AUnknownNCT01938339

Seoul National University Hospital60 enrolled

Overview

To development of clinical assessment technique using multi-radiotracer positron emission tomography/magnetic resonance (PET/MR) in prostate cancer * to establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer * to establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer and early detection of recurrent prostate cancer

To establish the optimal imaging technique of PET/MR using multiple radioactive tracers for prostate cancer * Recruiting 30 patients with prostate cancer ahead to radical prostatectomy * PET/MR using 18F-choline with dedicated prostate MRI in all patients * PET/MR using 18fluoride(F)-fluorodeoxyglucose(FDG)in all patients after 2-7 days * PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR * outcome assessment: comparison of scan time, image quality, tumor detection rate, standardized uptake values of lesions * establishing optimal imaging technique for prostate PET/MR To establish the imaging biomarker using PET/MR for clinical assessment of prostate cancer * comparison of findings on PET/MR, MRI and PET/CT with pathological mapping after radical prostatectomy * outcome assessment: accuracy of PET/MR for localization and staging of prostate cancer compared with MRI only and PET/CT only To establish the imaging biomarker using PET/MR for early detection of recurrent prostate cancer * Recruiting 15 patients with recurrent prostate cancer treated by surgery, hormone, or radiation therapy * Recruiting 15 patients with treated prostate cancer without recurrence * PET/MR using 18F-choline with dedicated prostate MRI in all patients * PET/MR using 18F-FDG in all patients after 2-7 days * PET/CT using 18F-FDG in all patient immediate after 18F-FDG PET/MR * comparison of findings on PET/MR, MRI, and PET/CT with clinical data in two patient groups with or without recurrent prostate cancer * outcome assessment: accuracy of PET/MR for early detection and localization of recurrent prostate cancer compared with MRI only and PET/CT only

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

Conditions

Prostate Cancer Recurrent Stage II Prostate Carcinoma Stage III Prostate Carcinoma

Interventions

PET/MRDEVICE

Multi-radiotracer PET/MR will be performed in patients with primary and recurrent prostate cancer

Eligibility

Sex: MALE

Medical Language ↔ Plain English

Inclusion Criteria: * patient with prostate cancer before treatment * patient with prostate cancer treated * patient with prostate cancer recurrent Exclusion Criteria: * patient with contraindication for MRI * Patient with severe renal impairment

Locations (1)

Seoul National University Hospital

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

accuracy of PET/MR predicting localization and staging of prostate cancer

analysis of accuracy of PET/MR predicting localization and staging of prostate cancer by comparison of PET/MR findings with pathological mapping images after radical prostatectomy

Time frame: 1 week after radical prostatectomy

Secondary Outcomes

accuracy of early detection and localization of recurrent prostate cancer

accuracy of PET/MR for early detection and localization of recurrence by comparison of PET/MR findings with clinical data in two groups of patients with or without recurrent prostate cancer

Time frame: 1 week after PET/MR imaging

Central Contacts

Jeong Yeon Cho, MD

CONTACT

82-2-2072-3074 radjycho@snu.ac.kr

Sang Youn Kim, MD

CONTACT

82-2-2072-3321 iwishluv@empas.com

Data from ClinicalTrials.gov

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