Prospective, Randomized, Multicenter Study to Assess the Safety and Effectiveness of the Orsiro Sirolimus-eluting Stent

Main Inclusion Criteria: * Subject must provide written informed consent * The target reference vessel diameter (RVD) is ≥ 2.50 mm and ≤ 3.75 mm assessed either visually or by online QCA. * Target lesion length is ≤ 26 mm (assessed either visual estimate or by online QCA) and can be covered by one study stent * Single de novo lesion with ≥ 50% and \< 100% stenosis in up to 2 coronary arteries Main Exclusion Criteria: * Subject has evidence of myocardial infarction within 72 hours prior to the index procedure * Planned intervention of non-target vessel(s) within 30 days after the index procedure * Planned intervention of target vessel(s) after the index procedure * Target lesion is located in the left main * Target lesion is located in or supplied by an arterial or venous bypass graft * Target lesion involves a side branch \> 2.0 mm in diameter by visual estimate or by online QCA * Proximal or distal to the target lesion located stenosis that might require future revascularization or impede run off