Characterization and Role of Mutations in Sodium-phosphate Cotransporters in Patients With Calcific Aortic Valve Disease

N/ATerminatedNCT01939678

Region Örebro County3 enrolled

Overview

The purpose of this study is to investigate whether mutations in genes coding for Na/Pi-cotransporters are associated with aortic valve calcification. A patient population with premature aortic valve calcification treated with aortic valve replacement will be screened for mutations in these specific genes. Furthermore, aortic valve tissue received from the operations, will be examined for the presence of Na/Pi-cotransporters, and for molecular characterization of the transporters.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Aortic Valve Stenosis

Eligibility

Sex: ALLMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with aortic valve calcification that will be treated with an aortic valve replacement. * Age ≤ 65 years. * Signed and dated informed consent. Exclusion Criteria: * Inability to provide informed consent * Earlier radiation therapy of the thorax * Severe renal disease (patients in treatment with dialysis)

Locations (1)

Department of Cardiology, Orebro University Hospital

Örebro, Sweden

Outcomes

Primary Outcomes

Mutations in sodium-phosphate cotransporters in patients with calcific aortic valve disease

Mutations in genes coding for Na/Pi-cotransporters

Time frame: At the time of aortic valve replacement

Data from ClinicalTrials.gov

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