Effect of Physical Training Combined Cardiac Resynchronization Therapy in Heart Failure Patients

N/ACompletedNCT01939795

University of Sao Paulo General Hospital40 enrolled

Overview

The investigators hypothesis that exercise training would potentiate the effects of cardiac resynchronization therapy in heart failure patients.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Heart Failure

Interventions

exercise training and/or CRTOTHER

Three 40-minute exercise sessions per week on a treadmill for four months

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * QRS\> 150 ms or 120-150ms associated dyssynchrony * The etiology can be idiopathic, ischemic, hypertensive and Chagas' disease * Ejection fraction \<35% * The optimal pharmacological treatment for heart failureExclusion Criteria: Exclusion Criteria: * Patients with pulmonary diseases, neurological diseases, renal, skeletal muscle diseases * Patients with contraindications to implant a cardiac pacemaker * Pregnancy * New York Heart Association functional class IV * Atrial fibrillation

Locations (1)

Thais Simoes Nobre Pires Santos

São Paulo, São Paulo, Brazil

Outcomes

Primary Outcomes

Sympathetic nerve activity

Sympathetic nerve activity will be assessed by microneurography

Time frame: 4 months

Secondary Outcomes

Peak oxygen consumption

Peak oxygen consumption will be determined by cardiopulmonary exercise testing

Time frame: 4 months

Quality of life

Quality of life will be assessed by questionnaire

Time frame: 4 months

Blood inflammatory markers

Blood inflammatory markers will be assessed by venipuncture

Time frame: 4 months

skeletal muscle strength

Muscular evaluation will be done muscle gene expression

Time frame: 4 months

Muscle Blood Flow

Forearm blood flow will be assessed by venous occlusion plethysmography

Time frame: 4 months

Data from ClinicalTrials.gov

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