Efficacy and Safety Study of SkinPlus-Hyal® to Nasolabial Fold

Inclusion Criteria: 1. Men and women aged over 20 2. Subjects who want to correct his/her nasolabial fold and have point 3 or 4 in WSRS of nasolabial fold and visually symmetric 3. Subjects who voluntarily decided the participation of the study and signed the informed consent 4. Subjects who agree contraception Exclusion Criteria: 1. Subjects who had anaphylaxis or a severe combined allergy, or an allergy to hyaluronic acid 2. Subjects who had eczema, infection, psoriasis, sclerosis, acne on the face 3. Subjects who have a skin disorder on the NLF area 4. Subjects who had permanent implants for dermal augmentation at the NLF area 5. Subjects who had a history of keloid formation or hypertrophic scar 6. Subjects who participated in other clinical trial within 3 months from screening date 7. Female subjects of childbearing potential who disagreed with medically acceptable contraception (e.g., condom, oral contraceptives continuing at least 3 months, injectable or insertable contraceptives, intrauterine contraceptive devices) during the trial 8. Subjects who is Drug abuser or alcoholism 9. Subjects who had previous treatment with Botox within 6 months from screening date 10. Subjects who had previous treatment for wrinkle with Retin-A within 1 months from screening date 11. Subjects who had previous treatment with tissue restorative biomaterials within 18 months from screening date 12. Patients who are not eligible for this study at the medical discretion of the Principal Investigator or Sub-investigator 13. Subjects who had antigen of HIV or type-B Hepatitis 14. Subjects who had anti-coagulant therapy within 2 weeks from the screening date 15. Patients who are not eligible for this study at the medical discretion of the Principal Investigator or Sub-investigator