Efficacy and Safety of Colistimethate Sodium Injection Vial to Treat Hospital-acquired Pneumonia in Adults

Inclusion Criteria: 1. Aged between 18-75, either male or female 2. Women of childbearing age having negative pregnancy test at the time of enrollment and agreeing to take effective contraceptive measures from the delivery to 7 \~14 days after stopping . 3. Defined as hospital-acquired pneumonia with following criteria 4. fever, axillary temperature ≥37.3℃, oral temperature≥37.8℃, tympanic temperature≥38.2℃, rectal temperature≥38.4℃ or hypothermia rectal temperature\<35℃ 5. WBC\>10000/μL or \<4000μL, neutrophils\>70%, rod neutrophils\>10% 6. Pathogens are or highly suspected to be aerobic gram-negative bacilli. 7. Before 72h of admin agents, drug treatment which used for Systemic antibacterial activity against gram-negative bacteria,is less than 48 hours. If it was more than 48h, there must be evidence for clinic failure, eg. continue fever.WBC and neutrophils irregular, or respiratory secretions/blood bacterial culture are positive. 8. Informed consent granted. Exclusion Criteria: 1. Pneumonia infected within 48h admission. 2. Before 72h of admin agents, drug treatment for Systemic antibacterial activity is more than 48 hours, unless clinical treatment failure . 3. Patients known or suspected by the single infection of aerobic Gram-positive cocci. 4. Patients known to have single or mixed infections by Stenotrophomonas narrow food Aeromonas or Burkholderia. 5. Patients with impaired consciousness. 6. Patients with primary pulmonary fibrosis, cystic fibrosis, lung cinerea pneumonia, active tuberculosis, Bronchial obstruction, history of obstructive pneumonia (mild to severe COPD were admission), primary lung cancer, other tumor metastasis to the lungs, bronchiectasis, lung abscess, empyema, non-infectious interstitial lung disease, pulmonary edema, atelectasis, pulmonary embolism, pulmonary eosinophil infiltration, pulmonary vasculitis, pleural effusion as the primary foci, aspiration pneumonia, fungal pneumonia and atypical pathogens pneumonia. 7. Patients have other bacterial infection lesions and require other antimicrobial drug therapy that may hinder the efficacy of the study drug evaluation. 8. Glucocorticoids（eg ,prednisone 20mg/d, treatment≥2 week） and immunosuppressant were used，or known HIV positive and immunocompromised. 9. Patients have immediate evidence of life-threatening diseases, including, but not limited to, acute congestive heart failure, acute coronary syndrome, or unstable arrhythmia. 10. Patients with sustainable shock after making adequate fluid resuscitation (systolic blood pressure \>90mmHg) for more than 2h and having evidence of hypoperfusion or need sympathomimetic drugs to keep steady blood pressure. 11. Patients with severe neutropenia syndrome (neutrophils\<500 cells/mm3) or expected to suffer severe reduction in neutrophil within 14days, or had taken G-GSF before 48h of study. 12. Any patients with end-stage disease. 13. Patients have medical record with multiple polymyxin anaphylactoid reactions.( urticaria, angioedema, anaphylaxis, rash, scaling, etc.) 14. Patients have Child Pugh C chronic liver disease, or liver function is abnormal.( AST or AST/ALT were greater than 5 times the upper limit of normal, total bilirubin greater than 2 times the upper limit of normal) 15. Patients in need of major surgery 16. Patients with moderate or severe renal impairment (CrCL\>50ml/min) 17. Patients have taken part in clinical trials of Colistimethate sodium。 18. Patients have taken part in other drug and instrument clinical trials. 19. Pregnant , breastfeeding and keep breastfeeding 20. Patients involving in planning or operation of study 21. Patients have poor compliance with study-specific procedures and related restrictions. 22. disease which may be harmful to patients or quality of data 23. History of epilepsy or myasthenia gravis.