Transcutaneous pO2, Transcutaneous pCO2 and Central Venous SO2 Variations to Define Fluid Responsiveness

N/ACompletedNCT01941472

Peking Union Medical College Hospital40 enrolled

Overview

Fluid challenge is often carried out in critical ill patients. Its responsiveness usually requires invasive monitoring. To use non-invasive methods is very tempting. Investigators hypothesize that transcutaneous pO2,transcutaneous pCO2 and Central Venous SO2 variations provide feasible estimation on fluid responsiveness in critical ill patients.

Study Type

INTERVENTIONAL

Allocation

Purpose

SCREENING

Masking

NONE

Enrollment

Conditions

Hypotension Shock Fluid Challenge Fluid Responsiveness

Interventions

fluid challengeOTHER

A bag of 500ml of normal saline or 4% gelatin (Gelofusine, B. Braun Medical (Suzhou) Company Limited, Suzhou, China) is infused within 15 minutes using a bag pressurized to 300 mmHg. All other treatments, including maintenance fluids, dose of vasoactive agents and ventilator settings, remain unchanged during the study period.

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * 18 years and older ICU patients; * Septic shock; * Monitored with PICCO or Swan-Ganz catheter; * The decision of fluid challenge made by the treating physician; Exclusion Criteria: * Evidence of fluid overload; * Pregnancy

Locations (1)

MICU of Peking Union Medical College Hospital

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

Fluid Responsiveness

Increase in cardiac index ≥ 10% after fluid challenge

Time frame: Immediately after fluid challenge, average 5 minutes

Data from ClinicalTrials.gov

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