VACcination In Methotrexate Treated Rheumatoid Arthritis Patients

Inclusion Criteria: * Adult (\>18 yeas old) suffers from rheumatoid arthritis considering ACR/EULAR 2010 criteria * Rheumatoid arthritis considering 3,2\<DAS\<5,1 * Patient did not treat by long term treatment or has stopped a treatment by sulfasalazine, hydroxychloroquine or methotrexate for at least 3 months * Patient has never treated by biotherapy * Patient has never vaccinated against pneumococcal * Patient has signed study consent form Exclusion Criteria: * Patient has ever treated by leflunomide or has treated previously by leflunomide (last 3 months) * Patient is currently treated by methotrexate or has treated previously by methotrexate (last 3 months) * Contraindication to methotrexate: renal insuffisance, alcoolic, chronic hepatisis, infectious condition, AIDS, hematological failure (cytopeny), pregnancy, obesity, diabet, respiratory disease, gastric ulcer * Contraindication to corticotherapy * Pregnancy or pregancy wish * Nursing * Absence of oral contraception for women of childbearing age * Patient of age protected by law et deprived of liberty * Subject who refuses to be vaccinated against pneumococcis agent * Previous history of vaccination allergy (anaphylactic shok, Quincke oedema...) * Gluten hypersensivity or intolerance * Other vaccination during the last month before inclusion * Ig perfusion during the last 3 months period before the study inclusion or during the study duration * Patient currently treated by anticoagulant or has not been stopped for at least 48h before the study inclusion or hemostasis failure which is contraindicated with muscular injection * Participation with an other clinical trial