This study aims at finding endophenotypes of schizophrenia at neuronal level by obtaining stem cells which is derived from adipose cells of subjects with heavy genetic loading for schizophrenia then differentiating them into neuronal cells.
Study Type
OBSERVATIONAL
Enrollment
24
Seoul National University Hospital
Seoul, South Korea
Structural and functional characteristics of neurons differentiated from adipose tissue derived stem cells in subjects with genetic high risk for schizophrenia and healthy controls
in vitro measurement of the expression of the neuronal markers for differentiated post-mitotic neuron, GABAergic/Glutamatergic neuron. The neuronal connectivity, neurites from soma and synaptic protein levels will be assessed. In addition, RNA and proteins expression (e.g. Glutamate/GABA receptors) , physiological function, and in vitro response to antipsychotics will be evaluated.
Time frame: three years
CAARMS(Comprehensive assessment of at risk mental states)
Clinical rating scale for prodromal symptoms of psychosis.
Time frame: Baseline
PANSS(Positive and Negative Syndrome Scale)
Clinical rating scale for the assessment of symptoms of schizophrenia.
Time frame: Baseline
Neurocognitive function test battery (composite)
Neurocognitive function battery comprising tests measuring subjects' intelligence, attention, memory, executive function and social cognitive function.
Time frame: Baseline
ERP(event-related potential) profile
ERP profile including P50, P30 \& MMN(Mismatch Negativity).
Time frame: Baseline
Structural/resting functional MRI data
Structural/resting functional MRI data
Time frame: Baseline
Proton MR spectroscopy
Molecular neuroimaging data measuring neurochemical composition profile.
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Time frame: Baseline
PET imaging data
PET imaging data measuring receptor availability of GABA(gamma-aminobutyric acid) and Glutamate.
Time frame: Baseline