Effect of Alveolar Minute Ventilation on Respiratory Gas Heat Content

N/ACompletedNCT01943227

University of California, Davis20 enrolled

Overview

This is a single site, prospective, non-blinded, non-randomized, non-interventional study designed to evaluate the effect of changes in alveolar minute ventilation on the measurement of respiratory heat loss (enthalpy).

This is a single site, prospective, non-blinded, non-randomized, noninterventional study designed to evaluate the effect of changes in alveolar minute ventilation on the measurement of respiratory heat loss (enthalpy). Each patient will serve as their own control. The study will enroll adult patients without cardiac or respiratory illness. It is designed to evaluate the effect of the ventilatory pattern (tidal volume, rate) on respiratory heat loss measured using the VQm™ monitor during standard intra-operative clinical care that requires positive pressure ventilation (PPV)

Study Type

OBSERVATIONAL

Enrollment

Conditions

Ventilation Perfusion Mismatch

Interventions

controlled positive pressure ventilation 9ml/kg tidal volumeOTHER

controlled positive pressure ventilation 9ml/kg tidal volume

controlled positive pressure ventilation 6ml/kg tidal volumeOTHER

controlled positive pressure ventilation 6ml/kg tidal volume

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * age greater than 18 years * scheduled for an elective surgical procedure with an anticipated duration of more than 2 hours requiring general anesthesia and positive pressure ventilation using an endotracheal tube * patient status ASA 1, 2 or 3 * no significant cardio-vascular or respiratory disease * supine surgical position Exclusion Criteria: * Adults unable to give primary consent * age less than 18 years * pregnancy * prisoners * pre-existing cardiac or pulmonary disease * infusion of inotropic drugs * positive end expiratory pressure (PEEP) requirements \>8 cm H2O * increased intra-abdominal pressure (e.g. planned surgical pneumoperitoneum or ascitis) * intra-operative patient position other than supine

Locations (1)

UC Davis Health System

Sacramento, California, United States

Outcomes

Primary Outcomes

Airway Enthalpy

Time frame: 12 months

Data from ClinicalTrials.gov

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