Early Saline Irrigation to Decrease Post-operative Endoscopic Debridement

N/ACompletedNCT01943370

University of Alberta25 enrolled

Overview

Nasal saline is a common treatment adjunct in the post-operative setting for endoscopic sinus surgery. However, the ideal timing and quantity of irrigation in the early post-operative period remains unknown. Proposed benefits of early, large volume irrigation include removal and softening of crusts, resulting in improved mucociliary clearance. The potential benefit of early large volume saline irrigation on post-operative day three to ease or reduce the need for early post-operative debridement has not been studied.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

SINGLE

Enrollment

Conditions

Chronic Rhinosinusitis

Interventions

Early saline irrigationOTHER

Initiation of post-operative saline irrigation earlier during the post-operative course

Routine IrrigationOTHER

Routine initiation of saline irrigation

Eligibility

Sex: ALLMin age: 17 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Adult patients * Diagnosis of CRS with or without polyposis * Undergoing bilateral endoscopic sinus surgery * Availability of pre-operative CT paranasal sinuses Exclusion Criteria: Patients with diagnosis of: * Primary ciliary dyskinesia * Immunodeficiency * Cystic fibrosis

Outcomes

Primary Outcomes

Pain

Pain and discomfort during early post-operative debridement on post-operative day 10

Time frame: Early post-operative (Day 10)

Secondary Outcomes

Endoscopic appearance

Early post-operative POSE score on post-operative day 10

Time frame: Early (post-operative day 10)

Late endoscopic appearance at 6 months

Late post-operative endoscopic POSE score at 6 months

Time frame: 6 months

Data from ClinicalTrials.gov

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