Substituted Frozen Embryo Transfer Cycles With GnRH-agonist Supplementation

Phase 4CompletedNCT01943812

Peter Humaidan287 enrolled

Overview

The aim of this study is to compare two FET protocols by modifying the substituted FET cycle in order to maintain a higher ongoing positive pregnancy rate and thus reduce the early pregnancy loss. Hypothesis: adding GnRH-agonist to the substituted cycle in FET treatment reduces the early pregnancy loss.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

287

Conditions

Pregnancy Loss Frozen Embryo Transfer

Interventions

Estradiol and progeteroneDRUG

Estradiol and progesterone

Eligibility

Sex: FEMALEMin age: 18 YearsMax age: 45 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Endometrial thickness ≥ 7 mm after stimulation * 18-45 years * IVF/ICSI fertilisation * BMI \> 18,5 \<30 kg/m2 * cycle length 25-34 days Exclusion Criteria: * endometrial thickness \< 7 mm or no triple layer endometrium and/or functional follicles * Uterine abnormality * Chronic medical disease * oocyte donation cycles

Locations (2)

IVF syd

Fredericia, Denmark

Fertility Clinic Regional Hospital Skive

Skive, Denmark

Outcomes

Primary Outcomes

Pregnancy loss rate

Time frame: Primary outcome is avaible after 12th week of gestational.

Secondary Outcomes

Pregnancy rate

Time frame: 14 days after embryo transfer.

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.