The Effects of Simvastatin on Th17 Cytokines and Th17 Polarizing Cytokine in COPD Patients

Inclusion Criteria: * Stable COPD without an exacerbation within 3 months prior to study entry * mild, moderate and severe COPD with or without treatments, regardless of COPD medications Exclusion Criteria: * Concomitant other chronic lung diseases including with TB and malignancy * HIV * Being on immunosuppressive drugs and systemic corticosteroids * Dyslipidemic patients with recent cardiovascular or cerebrovascular disease within 6 month prior to study entry * Cognitive impairment * Currently on macrolides, azole anti-fungal agents, amiodarone and amlodipine