The Association With Peptic Ulcer Disease and Hepatic Vein Pressure Gradient

N/ACompletedNCT01944878

Chuncheon Sacred Heart Hospital455 enrolled

Overview

The aim of this study is to assess the role of portal hypertension of peptic ulcer disease in liver cirrhosis and chronic hepatitis.

Retrospective case-control study * Investigators will analyze the medical records of hepatic vein pressure gradient (HVPG) and esophagogastroduodenoscopy (EGD) cases who had liver cirrhosis (LC) or chronic hepatitis in a single tertiary hospital (Chuncheon Sacred Heart hospital, Korea) within 2008\~2012. * Portal hypertension is assessed using HVPG measurement via transjugular approach. * Peptic ulcer is evaluated through EGD within 3 months of HVPG measurement * The association of Peptic ulcer with LC, chronic hepatitis and total population (LC or chronic hepatitis) will be assessed by univariate and multivariate analysis * There is no specific time frame, because this study is retrospective observational study, however EGD data is enrolled if it was done within 3 month from HVPG measurement.

Study Type

OBSERVATIONAL

Enrollment

455

Conditions

Cirrhosis Chronic Liver Disease

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * The patients who underwent hepatic vein pressure gradient (HVPG) measurement and esophagogastroduodenoscopy (EGD) and also had LC or chronic hepatitis Exclusion Criteria: * The patients who have missing or incomplete HVPG or EGD data * The patients who underwent gastrectomy * The patients who have systemic malignancy

Locations (1)

Chuncheon Sacred Heart hospital

Chuncheon, Gangwon-do, South Korea

Outcomes

Primary Outcomes

The Association of HVPG and PUD in Patients With Liver Cirrhosis

The association of hepatic vein pressure gradient that reflects portal hypertension and peptic ulcer disease in patients with liver cirrhosis was assessed statistically. (NO specific time frame, only confined to 2009 to 2012, when the HVPG measurement was done). The Mann-Whitney test was used to evaluate the association between PUD or not and HVPG degree, by SPSS software.

Time frame: Retrospective case-control study (from 2009 to 2012, up to 3 years)

Secondary Outcomes

The Association Between PUD and HVPG in Patients With Chronic Hepatitis

Time frame: Retrospective case-control study (from 2009 to 2012, up to 3 years)

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.