This study evaluates the intervention of the 1) sodium-restricted diet, or 2) diuretic, or 3) placebo pill in the treatment of obstructive sleep apnea in adults.
Men with apnea-hypopnea index greater than 30/hour will be included and randomly assigned into three groups: sodium-restricted diet, or diuretic, or control. The intervention will last one week. The diuretic group will receive combined spironolactone 100mg plus furosemide 20mg daily. The diet group will receive a regimen with a maximum intake of three grams of sodium per day. The control group will receive a placebo pill and will maintain all eating habits.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
54
Active drug (spironolactone 100 mg plus furosemide 20 mg).
The sodium-restricted diet will enforce some rules: do not use salt in cooking; do not use the salt shaker; do not ingest any industrialized food; to eat fresh salads and vegetables; do not add high-sodium seasonings, among others. The complete dietary rules will be delivered to each volunteer in a four page handout.
The placebo group will receive cellulose-based placebo pills with identical pills and flasks to active drug.
Hospital de Clinicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil
Apnea-Hypopnea Index
Number of apneas/hour
Time frame: One week
Somnolence scale (Epworth) and ventilatory parameters
Time frame: One week
Glycolipid profile
Total and HDL Cholesterol, Triglycerides, and glucose
Time frame: One week
Aldosterone Renin Level Activity
Serum renin and aldosterone
Time frame: One week
Dosages of urinary 24h
Aldosterone, sodium, potassium, urea, and creatinine
Time frame: One week
Inflammatory marker
C reactive protein
Time frame: One week
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