Remote Ischemic Preconditioning Induces Myocardial RISK Signaling Pathway in Patients Undergoing Valvular Heart Surgery

Phase 4CompletedNCT01946087

Yonsei University79 enrolled

Overview

The aim of this study is to investigate whether RIPC protects the heart against ischemia reperfusion injury on the concentrically hypertrophied myocardium

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Patients With Elective Aortic Valve Replacement

Interventions

Remote ischemic preconditioning at left upper armPROCEDURE

Placement of automated cuff-inflator on the left upper arm after induction of anesthesia RIPCgroup-3 cycles of 5 min ischemia (300 mmHg inflation) \& 5 min reperfusion (deflation)

Control groupPROCEDURE

keeping the cuff deflated

Eligibility

Sex: ALLMin age: 20 YearsMax age: 90 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients aged ≥20 years with severe degenerative AS presenting concentric remodeling of the LV, who were scheduled for AVR Exclusion Criteria: * diabetes mellitus, * coronary stenosis ≥70%, * renal failure (serum creatinine \> 2.0 mg/dL), * upper arm peripheral vascular disease, * LV ejection fraction \<50%

Locations (1)

Yonsei University College of Medicine

Seoul, South Korea

Outcomes

Primary Outcomes

Serum levels of CK-MB and Tn-T

Time frame: baseline

Serum levels of CK-MB and Tn-T

Time frame: 12-hour after surgery

Serum levels of CK-MB and Tn-T

Time frame: 24-hour after surgery

Secondary Outcomes

Myocardial activation of protective signaling pathway

Time frame: Before commencement of CPB

Myocardial activation of protective signaling pathway

Time frame: After taking off CPB

Data from ClinicalTrials.gov

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