The overall objective of the study is to assess the feasibility of implementing a quantitative process of florbetapir F 18 scan interpretation. The hypothesis is that the use of quantitative analysis will increase the accuracy of florbetapir F 18 scan interpretation.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
SINGLE
Enrollment
96
No Florbetapir F 18 will be administered in this study.
Research Site
Philadelphia, Pennsylvania, United States
Change in Total Accuracy (MIMNeuro Software, Low Accuracy Readers)
Evaluate whether the addition of quantitation as an adjunct to qualitative interpretations (VisQ) significantly improved the total accuracy of Amyvid scan interpretation in lower accuracy readers. Only the 46 scans with autopsy from A07/A16 are used for this outcome measure.
Time frame: Scan acquired 50-60 min post-injection
Change in Total Accuracy (Siemens Syngo.PET Software, Experimental Arm Low Accuracy Readers)
Evaluate whether the addition of quantitation as an adjunct to qualitative interpretations (VisQ) significantly improved the total accuracy of Amyvid scan interpretation in lower accuracy readers. Only the 46 scans with autopsy from A07/A16 are used for this outcome measure.
Time frame: Scan acquired 50-60 min post-injection
Change in Total Accuracy (MIMNeuro Software, All Readers)
Evaluate whether the total accuracy of Amyvid VisQ interpretation was non-inferior to the qualitative scan interpretation alone. Only the 46 scans with autopsy from A07/A16 are used for this outcome measure.
Time frame: Scan acquired 50-60 min post-injection
Change in Reliability (MIMNeuro Software)
Evaluate whether VisQ interpretation significantly improved the reliability of Amyvid scan interpretation compared with qualitative scan interpretation alone. The scan interpretation reliability will be evaluated using Fleiss' Kappa statistics.
Time frame: Scan acquired 50-60 min post-injection
Change in Total Accuracy (Siemens Syngo.PET Software, Experimental Arm All Readers)
Evaluate whether the total accuracy of Amyvid VisQ interpretation was non-inferior to the qualitative scan interpretation alone. Only the 46 scans with autopsy from A07/A16 are used for this outcome measure.
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Time frame: Scan acquired 50-60 min post-injection
Change in Reliability (Siemens Syngo.PET Software)
Evaluate whether VisQ interpretation significantly improved the reliability of Amyvid scan interpretation compared with qualitative scan interpretations alone. The scan interpretation reliability will be evaluated using Fleiss' Kappa statistics.
Time frame: Scan acquired 50-60 min post-injection