Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
Study Type
OBSERVATIONAL
Enrollment
1,961,286
University College London
London, United Kingdom
Risk of atherosclerotic disease in patients with high or low heart rate
Hazard ratios will be also presenting associations between heart rate and initial presentation of different cardiovascular diseases. These associations will be also measured between different levels of heart rate and CVDs stratified by: * by sex * gender * a range of risk factors (such as physical activity, smoking status, drinking status, etc.)
Time frame: Participants were followed until the first Coronary disease event (an expected average of 5 years)
Incidence proportions and life time risk for Cardiovascular diseases
Subhazard Ratios and Cumulative Incidence estimation of the risk of 12 different cardiovascular diseases adjusted for the 4 different levels of heart rate (\<60, 60-74, 75-89, \>90), age and sex in a lifetime period
Time frame: Participants were followed until the first Coronary disease event (an expected average of 5 years)
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