The risk of restenosis in the treatment of coronary artery disease has significantly lessened thanks to the introduction of Drug eluting stent. Yet, debates on the efficacy and safety of stents in complex lesions or patients have been circulated. Recently, PCI in multiple lesions is universally performed with the development of effective stents in various kinds in the clinics. However, a randomized study is rare for multi-vessel coronary artery disease in real procedural environments. The primary purpose of this study is to evaluate the clinical progress of biolimus A9-eluting stent and zotarolimus-eluting stent in multi-vessel coronary artery disease.
The patients who need multi-vessel stenting with multi-vessel coronary artery disease will be enrolled.Each randomization of the enrolled subjects will be done 1:1 (biolimus A9-eluting stent : zotarolimus-eluting stent). Randomization will be stratified by two factors: Diabetes mellitus and Acute coronary syndrome.Clinical follow-up will occur at the following time points; 1 month, 1 year and 2 years.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
932
Percutaneous Transluminal coronary angioplasty and Intervention will be performed in both of randomized groups of biolimus A9 eluting stent and zotarolimus eluting stent
Chonnam National University Hospital
Kwangju, Chonnam, South Korea
Ulsan University Hospital
Ulsan, Gyeongsangbuk-do, South Korea
Inje University Ilsan Paik Hospital
Ilsan, Kyeongki, South Korea
Kosin University Hospital
Busan, South Korea
Daegu Catholic University Medical Center
Daegu, South Korea
Daegu Fatima Hospital
Daegu, South Korea
KyungPook National University Hospital
Daegu, South Korea
Yeungnam University Hospital
Daegu, South Korea
Seoul National University Hospital
Seoul, South Korea
2-year composite end points
All cause death, non fatal myocardial infarction, any revascularization
Time frame: up to 2 years
All cause death
All cause death
Time frame: up to 2 years
non-cardiac death
non-cardiac death
Time frame: up to 2 years
cardiac death
cardiac death
Time frame: up to 2 years
non fatal myocardial infarction
non fatal myocardial infarction
Time frame: up to 2 years
Any revascularization
Any revascularization
Time frame: up to 2 years
Target lesion revascularization
Target lesion revascularization
Time frame: up to 2 years
Target vessel revascularization
Target vessel revascularization
Time frame: up to 2 years
stent thrombosis
stent thrombosis
Time frame: up to 2 years
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.